Saget, who was best known for his role as widowed father Danny Tanner in ABC's "Full House," was found unresponsive in his hotel room at The Ritz-Carlton in Orlando, Florida, at about 4 p.m. Sunday, police said. He was pronounced dead on the scene.
The Orange County Sheriff's Office told USA TODAY in a statement that detectives have found "no signs of foul play or drug use in this case." The Medical Examiner’s Office will ultimately determine the cause of death.
Saget's family confirmed his death in a statement provided to USA TODAY.
"We are devastated to confirm that our beloved Bob passed away today," the statement said. "He was everything to us and we want you to know how much he loved his fans, performing live and bringing people from all walks of life together with laughter.
“Though we ask for privacy at this time, we invite you to join us in remembering the love and laughter that Bob brought to the world."
'Loved him so much':John Stamos, Candace Cameron Bure, more mourn 'Full House' dad Bob Saget
Saget, the wisecracking host of "America's Funniest Home Videos" from 1989 to 1997, had been traveling the country with the "I Don't Do Negative" tour and performed a two-hour set in Jacksonville, Florida, on Saturday.
His final Instagram post on Saturday night was filled with hope.
"I loved tonight’s show in Jacksonville," Saget wrote. "Very appreciative and fun audiences. I had no idea I did a two hour set tonight. I’m back in comedy like I was when I was 26. I guess I’m finding my new voice and loving every moment of it. A’ight, see you in two weeks.
"Goin’ everywhere until I get the special shot. And then probably keep going cause I’m addicted to this," he added, signing off with "Peace out. ✌️"
Saget played the sweetly neurotic father of "Full House" from 1987 to 1995 opposite Jesse (John Stamos), Joey (Dave Coulier) and his TV daughters D.J. (Candace Cameron), Stephanie (Jodie Sweetin) and Michelle (a role shared by Mary-Kate and Ashley Olsen).
Stamos expressed his grief on Twitter Sunday. "I am broken. I am gutted. I am in complete and utter shock. I will never ever have another friend like him," Stamos wrote. "I love you so much Bobby."